Freezing in Parkinson's Disease: A Spatiotemporal Motor Disorder Beyond Gait
Identifieur interne : 001118 ( Main/Exploration ); précédent : 001117; suivant : 001119Freezing in Parkinson's Disease: A Spatiotemporal Motor Disorder Beyond Gait
Auteurs : Sarah Vercruysse [Belgique] ; Joke Spildooren [Belgique] ; Elke Heremans [Belgique] ; Jochen Vandenbossche [Belgique] ; Oron Levin [Belgique] ; Nicole Wenderoth [Belgique] ; Stephan P. Swinnen [Belgique] ; Luc Janssens [Belgique] ; Wim Vandenberghe [Belgique] ; Alice Nieuwboer [Belgique]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation.
English descriptors
- KwdEn :
Abstract
Freezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non-freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted severity of upper limb freezing, present in 9 freezers, and of foot freezing, present in 8 freezers. Similar to gait, small-amplitude movements tended to trigger upper limb freezing, which was preceded by hastened movement and a strong amplitude breakdown. Upper limb freezing power spectra were broadband, including increased energy in the "freeze band" (3-8 Hz). Contrary to FOG, unilateral upper limb freezing was common and occurred mainly on the disease-dominant side. The findings emphasize that a core motor problem underlies freezing which can affect various movement effectors. This deficit may originate on the disease-dominant body side and interfere with amplitude and timing regulation during repetitive limb movements. These results may shift current thinking on the origins of freezing as being not exclusively a gait failure.
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Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0113819</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0113819 INIST</idno><idno type="RBID">Pascal:12-0113819</idno><idno type="wicri:Area/PascalFrancis/Corpus">000271</idno><idno type="wicri:Area/PascalFrancis/Curation">002A43</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000191</idno><idno type="wicri:doubleKey">0885-3185:2012:Vercruysse S:freezing:in:parkinson</idno><idno type="wicri:Area/Main/Merge">001170</idno><idno type="wicri:Area/Main/Curation">001118</idno><idno type="wicri:Area/Main/Exploration">001118</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Freezing in Parkinson's Disease: A Spatiotemporal Motor Disorder Beyond Gait</title><author><name sortKey="Vercruysse, Sarah" sort="Vercruysse, Sarah" uniqKey="Vercruysse S" first="Sarah" last="Vercruysse">Sarah Vercruysse</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Spildooren, Joke" sort="Spildooren, Joke" uniqKey="Spildooren J" first="Joke" last="Spildooren">Joke Spildooren</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Heremans, Elke" sort="Heremans, Elke" uniqKey="Heremans E" first="Elke" last="Heremans">Elke Heremans</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Kinesiology, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Vandenbossche, Jochen" sort="Vandenbossche, Jochen" uniqKey="Vandenbossche J" first="Jochen" last="Vandenbossche">Jochen Vandenbossche</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurological Rehabilitation, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>4 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Cognitive Psychology, Vrije Universiteit Brussel</s1><s2>Brussels</s2><s3>BEL</s3><sZ>4 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Levin, Oron" sort="Levin, Oron" uniqKey="Levin O" first="Oron" last="Levin">Oron Levin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Kinesiology, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Wenderoth, Nicole" sort="Wenderoth, Nicole" uniqKey="Wenderoth N" first="Nicole" last="Wenderoth">Nicole Wenderoth</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Kinesiology, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Swinnen, Stephan P" sort="Swinnen, Stephan P" uniqKey="Swinnen S" first="Stephan P." last="Swinnen">Stephan P. Swinnen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Kinesiology, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Janssens, Luc" sort="Janssens, Luc" uniqKey="Janssens L" first="Luc" last="Janssens">Luc Janssens</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Groep T-International University College Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Groep T-International University College Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Vandenberghe, Wim" sort="Vandenberghe, Wim" uniqKey="Vandenberghe W" first="Wim" last="Vandenberghe">Wim Vandenberghe</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospitals Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Rehabilitation Sciences, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Freezing</term><term>Gait disorder</term><term>Motion</term><term>Motor system disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Spectral analysis</term><term>Upper limb</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble moteur</term><term>Trouble de la marche</term><term>Pathologie du système nerveux</term><term>Congélation</term><term>Membre supérieur</term><term>Mouvement</term><term>Analyse spectrale</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Congélation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non-freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted severity of upper limb freezing, present in 9 freezers, and of foot freezing, present in 8 freezers. Similar to gait, small-amplitude movements tended to trigger upper limb freezing, which was preceded by hastened movement and a strong amplitude breakdown. Upper limb freezing power spectra were broadband, including increased energy in the "freeze band" (3-8 Hz). Contrary to FOG, unilateral upper limb freezing was common and occurred mainly on the disease-dominant side. The findings emphasize that a core motor problem underlies freezing which can affect various movement effectors. This deficit may originate on the disease-dominant body side and interfere with amplitude and timing regulation during repetitive limb movements. These results may shift current thinking on the origins of freezing as being not exclusively a gait failure.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><noRegion><name sortKey="Vercruysse, Sarah" sort="Vercruysse, Sarah" uniqKey="Vercruysse S" first="Sarah" last="Vercruysse">Sarah Vercruysse</name></noRegion><name sortKey="Heremans, Elke" sort="Heremans, Elke" uniqKey="Heremans E" first="Elke" last="Heremans">Elke Heremans</name><name sortKey="Janssens, Luc" sort="Janssens, Luc" uniqKey="Janssens L" first="Luc" last="Janssens">Luc Janssens</name><name sortKey="Levin, Oron" sort="Levin, Oron" uniqKey="Levin O" first="Oron" last="Levin">Oron Levin</name><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><name sortKey="Spildooren, Joke" sort="Spildooren, Joke" uniqKey="Spildooren J" first="Joke" last="Spildooren">Joke Spildooren</name><name sortKey="Swinnen, Stephan P" sort="Swinnen, Stephan P" uniqKey="Swinnen S" first="Stephan P." last="Swinnen">Stephan P. Swinnen</name><name sortKey="Vandenberghe, Wim" sort="Vandenberghe, Wim" uniqKey="Vandenberghe W" first="Wim" last="Vandenberghe">Wim Vandenberghe</name><name sortKey="Vandenbossche, Jochen" sort="Vandenbossche, Jochen" uniqKey="Vandenbossche J" first="Jochen" last="Vandenbossche">Jochen Vandenbossche</name><name sortKey="Vandenbossche, Jochen" sort="Vandenbossche, Jochen" uniqKey="Vandenbossche J" first="Jochen" last="Vandenbossche">Jochen Vandenbossche</name><name sortKey="Wenderoth, Nicole" sort="Wenderoth, Nicole" uniqKey="Wenderoth N" first="Nicole" last="Wenderoth">Nicole Wenderoth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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